Biography
Dr. Lai leads a NIH-funded clinical and translational research program focused on frailty, sarcopenia, nutrition, and outcomes in patients with chronic liver disease, with a particular emphasis on individuals undergoing liver transplantation. Her work advances whole-person, data-driven approaches aimed at preserving function, resilience, and health across the liver transplant journey. Her research has been continuously supported by numerous organizations including the National Institutes of Health (NIH), American Association for the Study of Liver Diseases (AASLD), American Gastroenterological Association (AGA), American College of Gastroenterology (ACG), American Society of Transplantation (AST), and American Federation for Aging Research (AFAR), and generous philanthropic support from her patients. She serves as director of the UCSF Health Advancing Research in Clinical Hepatology (ARCH)—the research arm of the UCSF Division of GI/Hepatology—as well as director of Patient-Facing Research Core of the NIH-funded UCSF Liver Center.
Dr. Lai earned her B.S. from Stanford University and combined MD/MBA degrees from Tufts University School of Medicine, then completed her clinical training in Internal Medicine at Columbia University, and gastroenterology and advanced/transplant hepatology fellowships at UCSF. Dr. Lai has received many honors for her work including the SF Business Times Top 40 under 40 Leader award, AGA Young Investigator Award in Clinical Science, AST Clinical Science Career Development Award, Young Investigator Award from the International Liver Transplantation Society, and the UCSF Distinction in Mentoring Award. She served as a standing member of the U.S. FDA Gastrointestinal Drug Advisory Committee. Currently, Dr. Lai serves as an Associate Editor for Hepatology (journal) and as a member of the AASLD Foundation Board of Trustees.
If you are interested in contributing to Dr. Lai's research program, please consider making a tax-deductible contribution: https://makeagift.ucsf.edu/LaiResearchFund
Education
| Institution | Degree | Dept or School | End Date |
|---|---|---|---|
| Columbia University Medical Center | Internship/Residency | Internal Medicine | |
| Nestle Nutrition Institute | Human Nutrition | ||
| Osher Collaborative for Integrative Health | Integrative Health | Integrative Health | |
| Stanford University | B.S. | ||
| Tufts University School of Medicine | M.D./M.B.A. | Medicine / Healthcare administration | |
| UCSF | Advanced Training in Clinical Research | ||
| UCSF | Fellowship in Advanced/Transplant Hepatology | ||
| UCSF | Fellowship in Gastroenterology |
Board Certifications
American Board of Internal Medicine
American Board of Internal Medicine - Gastroenterology
Awards & Honors
| Award | Conferred By | Date |
|---|---|---|
| Clinical Science Established Investigator Award | American Society of Transplantation | 2024 |
| Distinction in Mentoring (UCSF Academic Senate) | UCSF | 2023 |
| Long-Term Mentor Award | UCSF Medical School | 2021 |
| Young Investigator Award in Clinical Science | American Gastroenterological Association (AGA) | 2020 |
| Floyd Rector Internal Medicine Research Mentoring Award | UCSF | 2019 |
| Fellow | American Society of Transplantation | 2017 |
| AST/Novartis Faculty Development Award (grant) | American Society of Transplantation | 2016 |
| Clinical Science Career Development Award | American Society of Transplantation | 2016 |
| New Investigator Award | American Geriatrics Society | 2015 |
| Young Investigator Award | International Liver Transplantation Society | 2015 |
| Top 40 under 40 | San Francisco Business Times | 2015 |
| Paul B. Beeson Scholar in Aging Research (grant) | American Federation for Aging Research | 2014 |
| Associate Scholar Genius Award (grant) | UCSF Pepper Center | 2014 |
| T. Franklin Williams Scholar (grant) | Association of Specialty Professors | 2013 |
| Junior Faculty Career Development Award (grant) | American College of Gastroenterology | 2012 |
| Transplant Hepatology Fellowship (grant) | American Association for the Study of Liver Diseases | 2011 |
| Clinical Research Award (grant) | American College of Gastrenterology | 2011 |
| Vanguard Award | International Liver Transplantation Society | 2011 |
| Sylvia Allison Kaplan Clinical Research Award | Northern California Kaiser Permanente | 2009 |
| Alpha Omega Alpha | Tufts University School of Medicine | 2005 |
Collaboration Interests
I am interested in:
- PhysicianScientist
Clinical Expertise
Alcoholic Liver Disease
Autoimmune Hepatitis
Cirrhosis
Drug-Induced Hepatitis
Fulminant Hepatic Failure
Hemochromatosis
Hepatitis B
Hepatitis C
Hepatocellular Carcinoma (Liver Cancer)
Liver Transplantation
Living Donor Liver Transplantation
Nonalcoholic Fatty Liver Disease
Polycystic Liver Disease
Primary Biliary Cirrhosis
Primary Sclerosing Cholangitis
Program Affiliations
UCSF Liver Center
In the News
Grants and Funding
- The spectrum of cognitive impairment including Alzheimer’s Disease and related dementias after liver transplantation | NIH/NIA | 2023-09-15 - 2028-08-31 | Role: PI
- Investigating the role of frailty on outcomes in acutely ill patients with cirrhosis undergoing liver transplantation in the acute care setting | NIH/NIDDK | 2023-07-15 - 2028-06-30 | Role: PI
- The spectrum of cognitive impairment including Alzheimer?s Disease and Related Dementias after liver transplantation | NIH | 2018-06-15 - 2028-05-31 | Role: PI
- UCSF Liver Center | NIH | 1985-07-01 - 2028-05-31 | Role: Co-Investigator
- Investigating the role of frailty on outcomes in acutely ill patients with cirrhosis undergoing liver transplantation in the acute care setting | NIH | 2023-07-15 - 2028-04-30 | Role: Principal Investigator
- The Impact of Frailty on Liver Transplant Outcomes in Older Adults with Hepatocellular Carcinoma | NIH | 2023-01-15 - 2027-12-31 | Role: Principal Investigator
- The Impact of Frailty on Liver Transplant Outcomes in Older Adults with Hepatocellular Carcinoma | NIH/NIA | 2023-01-15 - 2027-12-31 | Role: PI
- Avoiding Cardiovascular Complications in Liver Transplantation through Novel Studies (ACCT NOW) in Hypertension | NIH | 2024-08-15 - 2027-05-31 | Role: Co-Investigator
- Development of a laboratory frailty index to improve prediction of mortality in patients with cirrhosis awaiting liver transplantation | NIH | 2020-05-01 - 2022-04-30 | Role: Principal Investigator
- Frailty and Functional Status in Older Liver Transplant Patients | NIH | 2014-09-15 - 2019-08-31 | Role: Principal Investigator
- Global Functional Status in the Older Liver Transplant Candidate | NIH | 2013-08-15 - 2015-07-31 | Role: Principal Investigator
Research Narrative
Dr. Lai has engaged in research investigating clinical outcomes in patients with chronic liver disease. Her research focuses on three main areas:
1) Understanding the impact of functional status and physiologic reserve (i.e., frailty) in patients with cirrhosis awaiting liver transplantation (actively enrolling)
2) Evaluating the association between chronic hepatitis C and systemic inflammation with Vitamin D status and bone mineral density (actively enrolling)
3) Characterizing patterns of liver allocation and distribution and their association with liver transplant outcomes (both pre- and post-transplant) on a national level
Research Interests
Impact of function status in patients on the liver-transplant waiting list
Hepatitis C virus (HCV)
Patterns of donor liver allocation and liver transplant outcomes
Publications
- Palliative Care Co-management at a Liver Transplant Center: A Mixed Methods Study.| |
PubMed
- Frailty 1 year after liver transplant is associated with long-term mortality: From the Functional Assessment in Liver Transplantation (FrAILT) Study.| |
PubMed
- The liver frailty index improves mortality risk prediction for GEMA-Na.| |
PubMed
- Frailty increases hospitalization rates in an ambulatory cohort of patients with cirrhosis: The NACSELD3 prospective cohort.| |
PubMed
- Characterizing Barriers to Living Donor Liver Transplantation for Pediatric Recipients: Qualitative Results from the SOCIAL-Tx Study.| |
PubMed
- Characterizing Abdominal Pain and Irritable Bowel Syndrome Among Individuals With Cirrhosis: Results of a Nationwide Survey.| |
PubMed
- Erratum: Clinically relevant cut-points for changes in the Liver Frailty Index are associated with waitlist mortality in patients with cirrhosis.| |
PubMed
- Erratum: The Liver Frailty Index enhances mortality risk prediction above and beyond MELD 3.0 alone.| |
PubMed
- Effect of MELD exception point policy changes on application and waitlist outcomes in primary sclerosing cholangitis-A retrospective cohort study.| |
PubMed
- Declining Opioid and Rising Nonopioid Analgesic Prescriptions Among 364,000 Veterans With Cirrhosis, 2010-2021.| |
PubMed